The 10 ^th anniversary of the world primary immunodeficiency week: A J Project celebration

Professional celebrations are unique as they represent long-term completion of purposeful work, togetherness, and public spirit. The starting point is always challenging the establishment a joint program should be both vaticinal inciting. such tradition usually follows birth discipline for many decades. Immunology had been well-established clinical research when European Federation Immunological Societies (EFIS) brought to life Day (DoI) increase awareness this important branch learning, on April 29, 2005 (https://www.dayofimmunology.org). Soon after this, World Primary Immunodeficiency Week (WPIW) was established dedicated increasing global primary immunodeficiency disorders (PIDs) or inborn errors immunity each year, since 2011 [1]. ambition PID professional community dedicate week instead day could well attributed underdevelopment diagnostics patient care compared other major fields immunology, allergy, autoimmunity. These annual events necessarily supplemented with even more educational programs. At turn millennium, it realized that PIDs were remarkably underdiagnosed in most Eastern- Central countries, number registered patients less than 10 [2]. dramatic statistics presented by Society Immunodeficiencies (ESID) into action ambitious physician education collaboration referred J Project (JP) Launched 2004, project started spread first Europe, from 2007 Eastern resulting year-by-year diagnosed treated [3]. key have meetings not only physicians but also health professionals, families, addition establishing national regional registries working groups [4]. has spreading east reaching countries like those Asia, JP now extended Russian Far East, Iran, Turkey [5, 6]. By 2020 grown 32 reached an average 3.6 per month (Figs. 1 2). organized all over prominent month. seen higher Meetings attributable DoI WPIW. Still, record 16 year outstanding unique. Although spontaneous, would hard attribute 10th anniversary This silent celebration showing sensitively how traditions WPIW may change our contribute progress wonderful discipline. Table shows list “April heroes” organizing these celebrating fully way, behalf whole community. subjects discussed at varied general treatment patients, infectious non-infectious manifestations PID, through immunization practices, parents, students, school teachers recent understanding disease-related risks COVID-19 [7]. We 300th meeting grandiose welcomed Montenegro, youngest member country (Table 1). changing ever its creation recognizing need then subsequently elsewhere, recently Asia Far-East Russia [6]. evolution, based recognition needs resulted changes rearrangements throughout Eurasia. prime focus shifted genetics education, thanks tremendous developments occurred field PIDs. In 2019, we expressed enthusiasm concerning success knowledge next-generation sequencing technologies disseminated, making possible define genetic basis 7]. However, took unexpected turn, forcing world face new challenges. very existence humanity threatened viral disease caused severe acute respiratory syndrome coronavirus (SARS-CoV-2) [8]. Most laboratories, centers, institutions changed direction focused their studies mechanisms, prevention, [9]. joined forces Casanova Lab Rockefeller University Paris, which involved running Human Genetic Effort, international spanning 50 hubs around world. decided extend participation playing role participating centers Eurasia unusual cases It will monogenic causes resistance SARS-CoV-2 infection. hope help slow pandemic and, eventually, eradicate disease, so able once again diseases, express feeling about commitment colleagues shared mission 2020, under unusually difficult circumstances. times, stronger carry responsibility. Extending scope traditional PID-COVID-19 gave strength dynamic another (Fig. invitation speakers present cutting-edge several aspect program. Pertinent discovery type interferon deficiency selected Nature one remarkable discoveries across science[10, 11]. authors two publications last year. step forward closer ESID. achieved ESID leaders Meetings, financial support Jeffrey Modell Foundation sponsors. Daughter milestones joining Uzbekistan Kyrgyzstan successful terms publishing papers: article Konya Declaration, achievements Siberia Project, published PID-focused Clin Immunol, set 11 articles Front area successes close orderly network vision timely summarize various parameters diagnosis comprehensive review outcomes companion programs improve complex countries. While resilient productive, encourage members efforts remain connected other, keep open doors regions strengthen connection partner organizations immunological societies EFIS Abolhassani, Hassan (Tehran, Iran); Avcin, Tadej (Ljubljana, Slovenia); Bahceciler, Nerin (Nicosia, North Cyprus); Bataneant, Mihaela (Timisoara, Romania); Belevtsev, Mikhail (Minsk, Belarus); Bernatowska, Ewa (Warsaw, Poland); Bolkov, Michail (Yekaterinburg, Russia); Bondarenko, Anastasia (Kiev, Ukraine); Boyarchuk, Oxana (Ternopil, Ciznar, Peter (Bratislava, Slovakia); Erd?s, Melinda (Budapest, Hungary); Guseva, Marina (St. Petersburg, Haraszti, Katalin Iritsyan, Sevan (Yerevan, Armenia); Keles, Sevgi (Konya, Turkey); Kostyuchenko, Larysa (Lviv, Kovzel, Elena (Nursultan, Kazakhstan); Kuli-Lito, Georgina (Tirana, Albania); Kurjane, Natalja (Riga, Latvia); Lázár, István (Debrecen, Litzman, Jiri (Brno, Czech Republic); Miltner, Noémi Mironska, Kristina (Skopje, Rep. Macedonia); Murdjeva, Marianna (Plovdiv, Bulgaria); Nasrullayeva, Gulnara (Baku, Azerbaijan); Naumova, Elissaveta (Sofia, Orozbekova, Bubusaira (Bishkek, Kyrgyzstan); Pac, Malgorzata Pagava, Karaman (Tbilisi, Georgia); Pocek, Lidija (Podgorica, Montenegro); Reisli, Ismail Rezaei, Nima Sciuca, Svetlana (Chisinau, Moldova); Sediva, Anna (Prague, Serban, Margit Sharapova, Snimshchikova, Irina (Orel, Toplak, Natasa Tuzankina, Tcyvkina, Galina (Vladivostok, Volokha, Alla Ukraine). author declares no commercial conflict interest.